PYCC 2482
1 - Taxon name
Sungouiella intermedia
2 - Classification
Ascomycota
3 - Strain (species name) changes
Blastodendrion intermedium; Candida intermedia var. intermedia
4 - Status of the strain
Type strain of Sungouiella intermedia
5 - Basis for identification
NA
6 - Identified by
NA
7 - Original strain number
ISA 1036
8 - Accession numbers in other collections
CBS 572;AATCC 9442;ATCC 14439;CCRC 21250;DBVPG 6218;IFO 0761;JCM 1607;KCTC 1701;NCTC 3147;NRRL Y-1512;NRRL Y-981
9 - Biological Safety Level
BSL-1
10 - Access and Benefit Sharing (CBD, Nagoya protocol)
No known ABS restrictions
11 - PYCC strain status
Open
12 - Mediterranean strain
No
13 - Substrate of isolation
faecas of American woman with tropical sprue
14 - Category of substrate
Human
15 - Locality
NA
16 - Country of origin
Puerto Rico
18 - Sample Collected by
NA
19 - Isolated by and date of isolation
R. Ciferri & Ashford, 1929
20 - Isolation details
NA
21 - Deposited by
CBS 572, 1952
22 - History
CBS > PYCC
23 - Preservation
Glass beads; 20% Glycerol; -150ºC Freeze dried ampoules
24 - Price per culture
90€
25 - Remarks
NA
26 - Medium for growth
YMA
DNA Sequence
Region
16S
Sequence Title
AY497755
Gene Bank Url
http://www.ncbi.nlm.nih.gov/nuccore/AY497755
DNA Sequence
Region
26S
Sequence Title
AY497683
Gene Bank Url
http://www.ncbi.nlm.nih.gov/nuccore/AY497683
DNA Sequence
Region
ITS
Sequence Title
AY500373
Gene Bank Url
http://www.ncbi.nlm.nih.gov/nuccore/AY500373
DNA Sequence
Region
ITS
Sequence Title
AF336840
Gene Bank Url
http://www.ncbi.nlm.nih.gov/nuccore/AF336840
F1 D-Glucose
+
F2 D-Galactose
W, D
F3 Maltose
W, D
F5 Sucrose
+
F6 a,a-Trehalose
W, D
F7 Melibiose
-
F8 Lactose
-
F9 Cellobiose
-
F10 Melezitose
W, D
F11 Raffinose
W, D
F12 Inulin
-
C41 Methanol
-
C42 Ethanol
+
T1 Growth at 25ºC
+
T1 Growth at 30ºC
+
T3 Growth at 35ºC
-
O4 50% D-Glucose
+
M1 Starch formation
-
M3 Urea hydrolysis
-
M4 Diazonium Blue B reaction
-
Title
Phylogenomic analysis of the Candida auris- Candida haemuli clade and related taxa in the Metschnikowiaceae, and proposal of thirteen new genera, fifty-five new combinations and nine new species

Author

F. Liu, Z.-D. Hu, X.-M. Zhao, W.-N. Zhao, Z.-X. Feng, A. Yurkov, S. Alwasel, T. Boekhout, K. Bensch, F.-L. Hui, F.-Y. Bai, Q.-M. Wang

Abstract

Candida is a polyphyletic genus of sexually reproducing yeasts in the Saccharomycotina with more than 400 species that occur in almost all families of the subclass and its name is strongly connected with the infectious disease candidiasis. During the last two decades, approximately half of the Candida species have been reassigned into more than 36 already existing genera and 14 newly proposed genera, but the polyphyletic feature of the genus largely remained. Candida auris is an important, globally emerging opportunistic pathogen that has caused life-threatening outbreaks in healthcare facilities worldwide. This species belongs to the Candida auris - Candida haemuli (CAH) clade in the Metschnikowiaceae, a clade that contains multidrug-resistant clinically relevant species, but also species isolated from natural environments. The clade is phylogenetically positioned remotely from the type species of the genus Candida that is Candida vulgaris (currently interpreted as a synonym of Candida tropicalis) and belongs to the family Debaryomycetaceae. Although previous phylogenetic and phylogenomic studies confirmed the position of C. auris in the Metschnikowiaceae, these analyses failed to resolve the position of the CAH clade within the family and its delimitation from the genera Clavispora and Metschnikowia. To resolve the position of the CAH clade, phylogenomic and comparative genomics analyses were carried out to address the phylogenetic position of C. auris and related species in the Metschnikowiaceae using several metrics, such as the average amino acid identity (AAI) values, the percentage of conserved proteins (POCP), and the presence-absence patterns of orthologs (PAPO).Based on those approaches, 13 new genera are proposed for various Candida and Hyphopichia species, including members of the CAH clade in the Metschnikowiaceae. As a result, C. auris and related species are reassigned to the genus Candidozyma. Fifty-five new combinations and nine new species are introduced, and this will reduce the polyphyly of the genus Candida.

Publication Date

Link to Publication

https://doi.org/10.3767/persoonia.2024.52.02